Hypothalamic involvement and biomarker candidacy in Alzheimer’s disease in Down syndrome
Stephanie S G Brown, Shahid Zaman, John T O'Brien · 2025
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Description
Stephanie Brown, Shahid Zaman, and John O'Brien scan a small brain hub in folks with Down traits to track Alzheimer wear, in a 2025 study. The hub makes the sole sleep switch chem in the brain. Poor sleep now counts as a risk mark for mind loss, so hub size may warn of wear.
Scans span more than three hundred fifty folks with Down traits plus kin checks. Hub size, set by skull share, shrinks in folks with mild loss or full mind loss. Small hubs track with worse thought scores in the checks. One front low sub part shrinks fast in clear Alzheimer cases. Sleep links may drive that fast wear.
Catalog record
| CREATOR | Stephanie S G Brown, Shahid Zaman, John T O'Brien |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |