Pilot Polygenic Risk Score in Health and Aging Brain Study ‐ Health Disparities (HABS‐HD) Mexican Americans
Mohammad Housini, Neetesh Pandey, Giuseppe Tosto, Robert Barber, HABS‐HD Study Team · 2025
Read Pilot Polygenic Risk Score in Health and Aging Brain Study ‐ Health Disparities (HABS‐HD) Mexican Americans by Mohammad Housini, Neetesh Pandey, Giuseppe Tosto, Robert Barber, HABS‐HD Study Team (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11712571.txt.
Description
Most gene risk research on Alzheimer disease has focused on people of European roots, leaving other groups understudied. Mohammad Housini and co-authors pilot a gene risk score for Mexican Americans in a 2025 study of brain aging and health gaps.
The pilot used data from 665 Mexican American adults with full health records. The team built a combined score from many small gene effects, weighing age, sex, a known risk gene, and ancestry markers. The full score sorted people by disease status better than the single risk gene alone. The authors call the pilot a first step toward risk tools that work for a group facing a fast-growing share of the disease burden.
Catalog record
| CREATOR | Mohammad Housini, Neetesh Pandey, Giuseppe Tosto, Robert Barber, HABS‐HD Study Team |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |