Quantitative multi‐parameter mapping of locus coeruleus in aging and Alzheimer’s disease
Sabrina Lenzoni, Grazia Daniela Femminella, Clare Loane, Elif Kurt, Millie Duckett, Nikolaus Weiskopf, Martina F Callaghan, Ray Dolan, Robert J Howard, Emrah Düzel, Dorothea Hämmerer · 2025
Read Quantitative multi‐parameter mapping of locus coeruleus in aging and Alzheimer’s disease by Sabrina Lenzoni, Grazia Daniela Femminella, Clare Loane, Elif Kurt, Millie Duckett, Nikolaus Weiskopf, Martina F Callaghan, Ray Dolan, Robert J Howard, Emrah Düzel, Dorothea Hämmerer (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11712563.txt.
Description
A tiny brainstem cluster called the locus coeruleus loses cells very early in Alzheimer's disease, so imaging it well could flag the disease sooner. Sabrina Lenzoni and co-authors tested a richer scan method in 2025, comparing young adults, older adults, and patients with the disease, with twenty-six people in each group. Their protocol yields several measured maps of tissue traits in a single session.
The cluster showed up best in the standard weighted images, and less clearly in most measured maps. Group gaps known from past work, with lower contrast in patients, appeared in weighted scans but not in the measured maps. One measured map type could not even be computed reliably in their setup. The authors call for better methods before measured maps can replace the standard scans here.
Catalog record
| CREATOR | Sabrina Lenzoni, Grazia Daniela Femminella, Clare Loane, Elif Kurt, Millie Duckett, Nikolaus Weiskopf, Martina F Callaghan, Ray Dolan, Robert J Howard, Emrah Düzel, Dorothea Hämmerer |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |