Effects of α‐synuclein pathology in Alzheimer’s disease and normal aging
Joseph R. Winer, Melanie J. Plastini, America Romero, Edward N. Wilson, Christina B. Young, Alexandra N. Trelle, Victor W. Henderson, Anthony D. Wagner, Kathleen L. Poston, Elizabeth Mormino · 2025
Read Effects of α‐synuclein pathology in Alzheimer’s disease and normal aging by Joseph R. Winer, Melanie J. Plastini, America Romero, Edward N. Wilson, Christina B. Young, Alexandra N. Trelle, Victor W. Henderson, Anthony D. Wagner, Kathleen L. Poston, Elizabeth Mormino (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11712561.txt.
Description
Joseph Winer and co-authors ask in this 2025 study how often a Parkinson's-linked protein pathology hides inside Alzheimer's disease and healthy aging. A spinal fluid seeding test flagged alpha-synuclein in sixty-nine Alzheimer's patients, 277 unimpaired volunteers, and a Lewy body comparison group.
As expected, four in five Lewy body cases tested positive. Sixteen percent of Alzheimer's patients and nine percent of unimpaired elders did too. Within Alzheimer's, positivity tracked male sex, deeper impairment, and higher tau. Unimpaired carriers skewed older, and in a memory substudy they scored like peers with full Alzheimer's markers. The authors suggest the hidden pathology on its own shapes decline. A simple fluid test could flag it early in clinics.
Catalog record
| CREATOR | Joseph R. Winer, Melanie J. Plastini, America Romero, Edward N. Wilson, Christina B. Young, Alexandra N. Trelle, Victor W. Henderson, Anthony D. Wagner, Kathleen L. Poston, Elizabeth Mormino |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |