Young Onset Neurocognitive Impairment, Amyloid Positivity, and Psychiatric Symptoms in Underrepresented Populations in the HABS‐HD Cohort
Julia E Culhane, Alyssa Arentoft, Vanessa A Guzman, Heining Cham, Desiree Byrd, Amanda T Calcetas, Monica Rivera Mindt · 2025
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Description
Julia Culhane and co-authors examine thinking problems, brain amyloid, and psychiatric symptoms in adults under sixty-five from underrepresented groups. Black and Latinx adults develop dementia at higher rates than white adults, yet early-onset cases in these groups are little studied. The team drew on a health and aging brain study with 1,562 participants.
Testing sorted each person as unimpaired, mildly impaired, or demented. Black participants showed higher rates of mild impairment than both white and Latinx participants. They carried more psychiatric symptoms, including mood change, anxiety, and irritability, as reported by study partners. Brain scans found no group differences in amyloid, the protein clump tied to Alzheimer's disease, and dementia rates were alike. The authors say the impairment gap in Black adults is real but not explained by amyloid. That points research toward causes, from vascular health to life stress, in these communities.
Catalog record
| CREATOR | Julia E Culhane, Alyssa Arentoft, Vanessa A Guzman, Heining Cham, Desiree Byrd, Amanda T Calcetas, Monica Rivera Mindt |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |