Potential effects of sweet almond oil in the treatment of Alzheimer’s disease targeting BDNF and TrkB: An In Silico Molecular docking and ADMET Evaluation Study
Rahmat Hassan Salis, Uduak Emmanuel Umana, Adamu Abubakar Sadeeq · 2025
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Description
Rahmat Hassan Salis, Uduak Emmanuel Umana, and Adamu Abubakar Sadeeq studied sweet almond oil compounds in 2025 as possible Alzheimer's aids. Their target was a brain growth factor and its receptor, which support neuron survival and memory. Loss of that signalling is tied to the disease.
Computer docking tested forty-two compounds from the oil against both targets, plus checks on drug-like traits and toxicity. Twelve compounds bound more strongly than a reference drug to the growth factor, and a few also beat it at the receptor. All leading compounds showed good brain entry in the models, no acute toxicity alerts, and sound drug-like profiles. The authors see therapeutic promise needing lab proof.
Catalog record
| CREATOR | Rahmat Hassan Salis, Uduak Emmanuel Umana, Adamu Abubakar Sadeeq |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |