Prediction of regional brain tau levels in early Alzheimer’s disease using plasma pTau217
Viswanath Devanarayan, Arnaud Charil, Thomas Doherty, Daniel A Llano, Yuanqing Ye, Erica Andreozzi, Jin Zhou, Pallavi Sachdev, Larisa Reyderman, Harald Hampel, Lynn D Kramer, Shobha Dhadda, Michael C Irizarry · 2025
Read Prediction of regional brain tau levels in early Alzheimer’s disease using plasma pTau217 by Viswanath Devanarayan, Arnaud Charil, Thomas Doherty, Daniel A Llano, Yuanqing Ye, Erica Andreozzi, Jin Zhou, Pallavi Sachdev, Larisa Reyderman, Harald Hampel, Lynn D Kramer, Shobha Dhadda, Michael C Irizarry (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11712491.txt.
Description
Viswanath Devanarayan and co-authors ask whether a blood test can stand in for brain scans when staging early Alzheimer's disease. Their 2025 paper uses the plasma pTau217 ratio, a measure of altered tau protein in blood, to predict tau levels across brain regions. Brain tau scans guide staging and trial screening, but they are costly and scarce.
The cohort held 242 amyloid-positive patients with early disease from a clinical trial. Models trained on sixty percent of patients predicted regional scan values in the held-out forty percent. Gradient boosting did the heavy lifting. The team also tested whether adding cognition scores, other fluid markers, or imaging improved the blood-only model. A cheap blood predictor could widen access to staging.
Catalog record
| CREATOR | Viswanath Devanarayan, Arnaud Charil, Thomas Doherty, Daniel A Llano, Yuanqing Ye, Erica Andreozzi, Jin Zhou, Pallavi Sachdev, Larisa Reyderman, Harald Hampel, Lynn D Kramer, Shobha Dhadda, Michael C Irizarry |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |