A polygenic score for executive function correlates with differential rates of cognitive decline
Nadia Dehghani, Lauren Massimo, Emma Rhodes, Katheryn A Q Cousins, Rory Boyle, Sheina Emrani, Jeffrey S Phillips, Daniel T Ohm, Melanie A Matyi, Vivianna M Van Deerlin, David J Irwin, Corey T McMillan · 2025
Read A polygenic score for executive function correlates with differential rates of cognitive decline by Nadia Dehghani, Lauren Massimo, Emma Rhodes, Katheryn A Q Cousins, Rory Boyle, Sheina Emrani, Jeffrey S Phillips, Daniel T Ohm, Melanie A Matyi, Vivianna M Van Deerlin, David J Irwin, Corey T McMillan (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11712485.txt.
Description
Nadia Dehghani and co-authors present a 2025 study on a genetic score and decline in frontotemporal degeneration. Executive function, the mind's control system, fails early in this disease family. A polygenic score sums many small gene effects on that function from population studies. The team computed it for 375 people with related diagnoses or normal cognition.
People in the lowest score third lost letter fluency faster over time. The gap held against both the middle and top thirds. Word meaning fluency, naming, and backward number recall showed no clear split. Fewer people had those measures, which weakens the tests. The authors say the score may flag who declines fastest in one skill. It could help sort patients for trials.
Catalog record
| CREATOR | Nadia Dehghani, Lauren Massimo, Emma Rhodes, Katheryn A Q Cousins, Rory Boyle, Sheina Emrani, Jeffrey S Phillips, Daniel T Ohm, Melanie A Matyi, Vivianna M Van Deerlin, David J Irwin, Corey T McMillan |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |