Genetic predisposition to AD and inflammation determine vulnerable brain regions to air pollution
Natalia Vilor‐Tejedor, Patricia Genius, Blanca Rodríguez‐Fernández, Federica Anastasi, Marta Cirach, Mark Nieuwenhuijsen, Carolina Minguillón, Manel Esteller, Arcadi Navarro, Juan Domingo Gispert · 2025
Read Genetic predisposition to AD and inflammation determine vulnerable brain regions to air pollution by Natalia Vilor‐Tejedor, Patricia Genius, Blanca Rodríguez‐Fernández, Federica Anastasi, Marta Cirach, Mark Nieuwenhuijsen, Carolina Minguillón, Manel Esteller, Arcadi Navarro, Juan Domingo Gispert (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11712472.txt.
Description
Natalia Vilor-Tejedor and co-authors ask whose brains air pollution hurts most in a 2025 study. Dirty air harms health broadly, but its marks on the brain before Alzheimer's symptoms appear were little mapped. Genes may decide who is vulnerable.
The cohort held 1,153 adults, many on the Alzheimer's path, with gene data, pollution estimates, and brain scans. Home addresses gave nitrogen oxide and particle exposure from land-use models. Genetic scores covered Alzheimer's risk, inflammation markers, and the APOE variant. Models corrected for age, sex, and schooling. Early results point to high genetic risk marking the regions where pollution bites. Gene-environment interplay is the paper's core claim.
Catalog record
| CREATOR | Natalia Vilor‐Tejedor, Patricia Genius, Blanca Rodríguez‐Fernández, Federica Anastasi, Marta Cirach, Mark Nieuwenhuijsen, Carolina Minguillón, Manel Esteller, Arcadi Navarro, Juan Domingo Gispert |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |