Mapping alterations in the hippocampal subfields in the ARTE10 mouse model of Alzheimer's disease using dMRI derived soma and neurite density maps
Syed Salman Shahid, Erin E Jarvis, Elizabeth R Butch, Scott E Snyder, Yu‐Chien Wu · 2025
Read Mapping alterations in the hippocampal subfields in the ARTE10 mouse model of Alzheimer's disease using dMRI derived soma and neurite density maps by Syed Salman Shahid, Erin E Jarvis, Elizabeth R Butch, Scott E Snyder, Yu‐Chien Wu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11712469.txt.
Description
Syed Salman Shahid and co-authors scan the memory center of the brain in a mouse model of Alzheimer's disease, hunting for early tissue changes, in a 2025 study. The hippocampus is hit early in the disease, as sticky amyloid builds up and nerve branches wither. Standard scans cannot separate those fine changes, so the team used a diffusion model that estimates cell body and fiber density.
Scans of ten-month-old model mice showed lower fiber density and higher cell body density across most hippocampal subfields, compared with normal littermates. The pattern fits loss of nerve branches alongside crowding from other cells. The authors say the method is sensitive enough to track disease changes in this key region.
Catalog record
| CREATOR | Syed Salman Shahid, Erin E Jarvis, Elizabeth R Butch, Scott E Snyder, Yu‐Chien Wu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |