Deletion of α5 integrin in endothelial cells ameliorates age–associated cognitive decline and increases survival in mice
Gregory W Hall, Saifudeen Ismael, Gregory J Bix · 2025
Read Deletion of α5 integrin in endothelial cells ameliorates age–associated cognitive decline and increases survival in mice by Gregory W Hall, Saifudeen Ismael, Gregory J Bix (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11712450.txt.
Description
Gregory Hall, Saifudeen Ismael, and Gregory Bix test removing a vessel receptor to slow brain aging in mice. Their twenty twenty-five paper targets alpha5 integrin, found mainly on vessel lining cells. Aging raises inflammation across body and blood, a process that can erode the blood-brain barrier.
As the barrier leaks, inflammatory marks seep into the brain and thought suffers. Deleting the receptor only in lining cells was the test. Treated mice showed less age-linked cognitive decline and lived longer. The result fingers one receptor as a driver of neurological inflammaging. Blocking it in people is far off, but the mouse proof gives drug hunters a clear target.
Catalog record
| CREATOR | Gregory W Hall, Saifudeen Ismael, Gregory J Bix |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |