Hyperphosphorylated Tau Targeting Human Serum Albumin Fusion Protein as Therapeutics for Alzheimer’s Disease
Sookhee Bang, Jeong Keun Song, Kwan Hee Lee · 2025
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Description
Sookhee Bang, Jeong Keun Song, and Kwan Hee Lee test a fusion protein against tau tangles in Alzheimer disease in a 2025 mouse study. Tangles of a changed tau protein, along with plaques, mark the disease and track with memory loss. The test protein, AL04, joins three parts, among them a carrier that helps it cross into the brain.
Mice bred to carry a human tau mutation got the protein or a salt solution every other week for 24 weeks, starting at three months old. Treated mice had less changed tau and fewer tangles in two brain areas tied to memory. The team also saw shifts in a brake on a tau cleaning enzyme and in cell cleanup markers.
Catalog record
| CREATOR | Sookhee Bang, Jeong Keun Song, Kwan Hee Lee |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |