VEGFR1‐mediated neuronal cell death following Aß1‐42 oligomers treatment‐ Implications in AD pathogenesis
Pritam Das · 2025
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Description
Pritam Das reports a 2025 laboratory study of a vessel growth receptor in Alzheimer's disease. Recent gene studies found the receptor, VEGFR-1, turned up in patient brains, while its sister receptor ran low. Higher levels of the first receptor tracked faster decline. Das asked whether the receptor itself harms neurons.
In donated brain tissue, the receptor clustered in damaged nerve fibers near amyloid plaques. Low oxygen or amyloid clumps raised the receptor in human nerve-like cells and mouse neurons, and the cells died. Silencing the receptor's gene saved the cells. Forcing extra receptor also killed neurons on its own. Das points to a signal chain that could be a drug target.
Catalog record
| CREATOR | Pritam Das |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |