Diffuse juxtacortical white matter texture changes in pre‐clinical Alzheimer’s disease
ADEMOLA E ILESANMI, Xueying Lyu, Emily McGrew, Paul A. Yushkevich, Sandhitsu R. Das, David A Wolk · 2025
Read Diffuse juxtacortical white matter texture changes in pre‐clinical Alzheimer’s disease by ADEMOLA E ILESANMI, Xueying Lyu, Emily McGrew, Paul A. Yushkevich, Sandhitsu R. Das, David A Wolk (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11712433.txt.
Description
Ademola Ilesanmi and co-authors read fine texture in brain scans in a 2025 Alzheimer's study. Early disease stages hide from standard size measures in single snapshots. Texture, the fine pattern of a scan, may catch subtler decay. The team tested texture traits in gray matter and in the white matter just under the cortex, in people with normal cognition.
Two cohorts split by amyloid status: healthy scans versus preclinical disease. Over a hundred healthy and a few dozen preclinical cases formed one cohort, with a second for checks. If texture sorts the groups, scans could flag risk before memory slips. That window is where future prevention drugs would need to act.
Catalog record
| CREATOR | ADEMOLA E ILESANMI, Xueying Lyu, Emily McGrew, Paul A. Yushkevich, Sandhitsu R. Das, David A Wolk |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |