High‐resolution 7 tesla postmortem MRI for quantitative analysis of structure‐pathology correlations in neurodegenerative diseases
Pulkit Khandelwal, Michael Tran Duong, Shokufeh Sadaghiani, Sydney A Lim, Amanda E Denning, Eunice Chung, Sadhana Ravikumar, Sadhana Ravikumar, Sanaz Arezoumandan, Claire Peterson, Madigan Bedard, Noah Capp, Ranjit Ittyerah, Elyse Migdal, Grace Choi, Emily Kopp, Bridget Loja Patino, Eusha Hasan, Jia · 2025
Read High‐resolution 7 tesla postmortem MRI for quantitative analysis of structure‐pathology correlations in neurodegenerative diseases by Pulkit Khandelwal, Michael Tran Duong, Shokufeh Sadaghiani, Sydney A Lim, Amanda E Denning, Eunice Chung, Sadhana Ravikumar, Sadhana Ravikumar, Sanaz Arezoumandan, Claire Peterson, Madigan Bedard, Noah Capp, Ranjit Ittyerah, Elyse Migdal, Grace Choi, Emily Kopp, Bridget Loja Patino, Eusha Hasan, Jia (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11712430.txt.
Description
Pulkit Khandelwal and a large team of co-authors present a 2025 method for scanning dead brain tissue at very fine detail. They used a strong 7 tesla MRI scanner on 135 human brain samples. A deep learning program then split each scan into cortex, deep brain parts, white matter, and damaged white matter spots.
The team matched scan measures, such as cortex thickness in sixteen spots, against lab ratings of tau protein, cell loss, and amyloid. Tau damage tracked thinner cortex in key areas, and white matter damage tracked smaller deep brain parts. The method gives researchers a shared way to link what scans show to what tissue tests find.
Catalog record
| CREATOR | Pulkit Khandelwal, Michael Tran Duong, Shokufeh Sadaghiani, Sydney A Lim, Amanda E Denning, Eunice Chung, Sadhana Ravikumar, Sadhana Ravikumar, Sanaz Arezoumandan, Claire Peterson, Madigan Bedard, Noah Capp, Ranjit Ittyerah, Elyse Migdal, Grace Choi, Emily Kopp, Bridget Loja Patino, Eusha Hasan, Jia |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |