Data‐driven progression patterns of Aβ, tau, α‐synuclein and vascular pathology in a clinical population
Sophie E Mastenbroek, Lyduine E Collij, Jacob W Vogel, Alexandra L Young, Olof Strandberg, Ruben Smith, Sebastian Palmqvist, Niklas Mattsson‐Carlgren, Frederik Barkhof, Rik Ossenkoppele, Oskar Hansson · 2025
Read Data‐driven progression patterns of Aβ, tau, α‐synuclein and vascular pathology in a clinical population by Sophie E Mastenbroek, Lyduine E Collij, Jacob W Vogel, Alexandra L Young, Olof Strandberg, Ruben Smith, Sebastian Palmqvist, Niklas Mattsson‐Carlgren, Frederik Barkhof, Rik Ossenkoppele, Oskar Hansson (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11712428.txt.
Description
Sophie Mastenbroek and co-authors chart how four brain pathologies unfold together in clinic patients in a study from 2025. Alzheimer's proteins amyloid and tau are two of them. A third, alpha-synuclein, marks Lewy body disease. Blood vessel damage is the fourth. New drugs target single pathologies, so sorting patients by their mix matters.
The BioFINDER-2 memory clinic cohort supplied over sixteen hundred subjects. They ranged from sharp-minded to full dementia. Fluid tests, brain scans, and vessel imaging fed a data-driven model. The model found subtypes defined by pathology patterns, not by symptoms alone. Each subtype's progression path can now be traced. Such maps support trials that match the drug to the pathology.
Catalog record
| CREATOR | Sophie E Mastenbroek, Lyduine E Collij, Jacob W Vogel, Alexandra L Young, Olof Strandberg, Ruben Smith, Sebastian Palmqvist, Niklas Mattsson‐Carlgren, Frederik Barkhof, Rik Ossenkoppele, Oskar Hansson |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |