Implication of Chronotherapy in mouse models of Alzheimer’s Disease
Yu Shi, Ricardo Salinas, William McRoberts, Stephen Rozen, Jordan Swint, George S Bloom, Ali Güler · 2025
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Description
Yu Shi and co-authors test whether timing-based therapy can sharpen the minds of Alzheimer model mice, in a 2025 study. Sleep problems appear early in the disease and track with later decline. Sleep is ruled by the body clock, which takes cues from light and meals. The team built a daily regimen to strengthen that clock.
The regimen, called LiFE, joined a shortened light phase with time-restricted feeding and exercise. Two mouse models of the disease received it. Treated mice did better on a water maze and an object memory test. Brain plaques and tau changes, though, stayed the same. Better sleep timing may aid thinking even when the disease's marks remain.
Catalog record
| CREATOR | Yu Shi, Ricardo Salinas, William McRoberts, Stephen Rozen, Jordan Swint, George S Bloom, Ali Güler |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 1 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |