Brain glucose metabolism changes acutely following exercise and tracks with the systemic lactate response
Zachary D. Green, Casey S. John, Anneka Blankenship, Paul J Kueck, Riley E Kemna, Chelsea N Johnson, Jonathan D Mahnken, Lauren Yoksh, Jeffrey M Burns, Joseph S. Donald, Eric D Vidoni, Jill K Morris · 2025
Read Brain glucose metabolism changes acutely following exercise and tracks with the systemic lactate response by Zachary D. Green, Casey S. John, Anneka Blankenship, Paul J Kueck, Riley E Kemna, Chelsea N Johnson, Jonathan D Mahnken, Lauren Yoksh, Jeffrey M Burns, Joseph S. Donald, Eric D Vidoni, Jill K Morris (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11712388.txt.
Description
Zachary Green and co-authors show that a single bout of exercise reshapes brain fuel use in older adults. Their 2025 trial covers sixty people over 60, half with cognitive impairment. Brain scans tracked glucose use at rest and during cycling, with blood draws in step.
Glucose use in grey matter dropped during exercise in both groups alike. Effort level did not change the size of the drop. Blood lactate climbed with exercise, more so at the harder setting. The two changes tracked each other across people. The authors read this as lactate stepping in as brain fuel, sparing glucose. The pattern held for impaired minds too.
Catalog record
| CREATOR | Zachary D. Green, Casey S. John, Anneka Blankenship, Paul J Kueck, Riley E Kemna, Chelsea N Johnson, Jonathan D Mahnken, Lauren Yoksh, Jeffrey M Burns, Joseph S. Donald, Eric D Vidoni, Jill K Morris |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |