SHIP1 phosphatase as a Late‐Onset Alzheimer’s Disease therapeutic target
Kratika Singhal, Adam K Hamdani, Cynthia D Jesudason, Daniel E Beck, Brent Clayton, Timothy I Richardson, Andrew D Mesecar · 2025
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Description
Kratika Singhal and co-authors study a protein called SHIP1 as a drug target in a 2025 report on late-onset Alzheimer's disease. A risk gene makes SHIP1, which damps a key signal in microglia, the brain's immune cells. That signal helps microglia clear amyloid, so blocking SHIP1 might restore cleanup.
The team made and purified pieces of the large protein to learn how each part works. To their surprise, the side parts did not change the core enzyme's speed in solution. A designed probe compound did block the protein at a seam between two of its parts, and X-ray work confirmed where it sits. The authors say this seam is a promising drug site, and they are screening more compounds against it.
Catalog record
| CREATOR | Kratika Singhal, Adam K Hamdani, Cynthia D Jesudason, Daniel E Beck, Brent Clayton, Timothy I Richardson, Andrew D Mesecar |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |