Neurodegeneration and acute neuronal injury drastically skew the p‐tau217/non‐p217 ratio in both CSF and plasma regardless of analytical technique – a mass spectrometry and Simoa study
Kaj Blennow · 2025
Read Neurodegeneration and acute neuronal injury drastically skew the p‐tau217/non‐p217 ratio in both CSF and plasma regardless of analytical technique – a mass spectrometry and Simoa study by Kaj Blennow (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11712376.txt.
Description
Kaj Blennow studies a blood marker for Alzheimer's disease in a 2025 paper. The marker, a changed form of tau protein, is read as a ratio against its unchanged form in some tests. That ratio was hoped to sharpen detection of Alzheimer's-type change.
Blennow shows that fast brain cell loss and sudden injury can skew the ratio in both spinal fluid and blood. The unchanged form rises with general cell damage, dragging the ratio with it. Data came from large groups with Alzheimer's, a prion disease, and acute injury, read by two methods. Clinics should read the ratio with care when other brain harm is present.
Catalog record
| CREATOR | Kaj Blennow |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |