Traditional Japanese Kampo Medicine Yokukansan decreases phosphorylated tau and oligomeric tau
Chika Mori, Ryota Yamamoto, Norimichi Shirafuji, Rei Asano, Hirohito Sasaki, Tomohisa Yamaguchi, Yuki Kitazaki, Yoshinori Endo, Soichi Enomoto, Tadanori Hamano · 2025
Read Traditional Japanese Kampo Medicine Yokukansan decreases phosphorylated tau and oligomeric tau by Chika Mori, Ryota Yamamoto, Norimichi Shirafuji, Rei Asano, Hirohito Sasaki, Tomohisa Yamaguchi, Yuki Kitazaki, Yoshinori Endo, Soichi Enomoto, Tadanori Hamano (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11712374.txt.
Description
Chika Mori and co-authors test a traditional Japanese herbal formula against the toxic tau protein of Alzheimer's disease. Their 2025 study uses a cell model engineered to produce human tau on command. In the Alzheimer's brain, tau tangled with phosphate groups forms the famous tangles, and smaller clumped forms are thought toxic. The formula, yokukansan, already had clinical hints of benefit in dementia.
Cells dosed with the formula showed less of the phosphorylated tau and less of the clumped form. The work probes whether the medicine speeds tau disposal, offering a mechanism for the clinical hints. Cell evidence is early, but it gives the old remedy a testable modern story.
Catalog record
| CREATOR | Chika Mori, Ryota Yamamoto, Norimichi Shirafuji, Rei Asano, Hirohito Sasaki, Tomohisa Yamaguchi, Yuki Kitazaki, Yoshinori Endo, Soichi Enomoto, Tadanori Hamano |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |