Decrowding Expansion Pathology for Visualization of Herpes Simplex Virus Type 1 and Tau Interaction in Alzheimer’s Disease
Katherine Araya, Pablo Valdes, Giulio Taglialatela · 2025
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Description
Katherine Araya, Pablo Valdes, and Giulio Taglialatela used a new imaging method in a 2025 study of Alzheimer disease. A common cold sore virus wakes up again and again in the brain. It has been tied to signs of the disease, such as toxic forms of the tau protein and sticky plaques. Seeing virus parts next to tau in brain tissue has been hard with older imaging.
Their method swells the tissue sample so tiny parts spread apart and can be seen with standard dyes. In that spread view, virus proteins can be mapped right next to tau in diseased tissue. The team aims to beat the blur of past methods and test how virus and tau may act on each other.
Catalog record
| CREATOR | Katherine Araya, Pablo Valdes, Giulio Taglialatela |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |