Fiber tract profiles of community dwelling older adults with LATE‐NC and associations with postmortem TDP‐43
Ashley Heywood, Julie A. Schneider, David A. Bennett, Konstantinos Arfanakis, Lei Wang · 2025
Read Fiber tract profiles of community dwelling older adults with LATE‐NC and associations with postmortem TDP‐43 by Ashley Heywood, Julie A. Schneider, David A. Bennett, Konstantinos Arfanakis, Lei Wang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11712291.txt.
Description
Ashley Heywood and co-authors map white matter tracts in older adults in a 2025 study of LATE, a brain change of old age tied to the protein TDP-43. They asked whether damage from the protein falls on set spots along fiber tracts rather than spreading evenly. Brain scans taken in life were matched with tissue checks after death.
The study covered sixty-three people from two long-running ageing cohorts, with an average age at death of about ninety-one. Just over a third carried TDP-43 changes. Tract profiles varied along each fiber bundle, as the team expected. One tract near the hippocampus showed weaker fiber quality exactly where the protein was present. The authors say such maps can sharpen how brain scans are read.
Catalog record
| CREATOR | Ashley Heywood, Julie A. Schneider, David A. Bennett, Konstantinos Arfanakis, Lei Wang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |