Therapeutic potential of D-amino acid oxidase inhibitors for cognitive impairment associated with schizophrenia: learnings from luvadaxistat
Ryan T Terry-Lorenzo, Reuben H Fan, Ni A Khin, Jaskaran B Singh · 2025
Read Therapeutic potential of D-amino acid oxidase inhibitors for cognitive impairment associated with schizophrenia: learnings from luvadaxistat by Ryan T Terry-Lorenzo, Reuben H Fan, Ni A Khin, Jaskaran B Singh (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11712274.txt.
Description
Ryan T Terry-Lorenzo and co-authors review a drug class aimed at the thinking problems of schizophrenia. The paper is listed as 2025 in the catalog, but the text itself says it was published in 2024. The target is a brain receptor whose weak activity is thought to drive negative and cognitive symptoms.
Directly stimulating that receptor risks harm, so trials have focused on a side site that native chemicals use. Blocking an enzyme that breaks down one of those chemicals is one indirect route. The review gathers lab and clinic evidence for that route, centered on one candidate drug, luvadaxistat. Early hopes for this class have met mixed trial results, and the authors weigh what the candidate's data teach for later trials.
Catalog record
| CREATOR | Ryan T Terry-Lorenzo, Reuben H Fan, Ni A Khin, Jaskaran B Singh |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |