NCRAD iPSCs: a vital resource for the Alzheimer’s disease research community
Kelly N Nudelman, Trever Jackson, Jeanine D Marshall, Kelley M Faber, Sarah K Ohlemacher, Michael C Edler, Tatiana M Foroud, Jason S Meyer · 2025
Read NCRAD iPSCs: a vital resource for the Alzheimer’s disease research community by Kelly N Nudelman, Trever Jackson, Jeanine D Marshall, Kelley M Faber, Sarah K Ohlemacher, Michael C Edler, Tatiana M Foroud, Jason S Meyer (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710849.txt.
Description
Eight researchers describe a growing bank of stem cells for Alzheimer's research, in a 2025 paper. The national repository NCRAD builds lines of induced pluripotent stem cells, which can be grown into brain cells in the lab. The lines are open by request to researchers studying Alzheimer's and related dementias.
Each line passes quality checks, including full genome sequencing. Of the lines from 183 donors, 120 have passed sequencing review so far. The set includes lines from ninety donors plus thirty matched edited lines. Many carry known risk variants in genes tied to Alzheimer's, such as APP and MAPT. Blood-based gene typing confirmed each line's identity. Adding genome data lets researchers pre-screen lines before experiments, saving time and money. The bank keeps expanding toward more variant types.
Catalog record
| CREATOR | Kelly N Nudelman, Trever Jackson, Jeanine D Marshall, Kelley M Faber, Sarah K Ohlemacher, Michael C Edler, Tatiana M Foroud, Jason S Meyer |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |