Characterizing Tau Neuropathology Across Brain Regions in Patients Carrying PSEN1 Jalisco Mutation
Bayla M Breningstall, Evan Abdollahi, Anne Hiniker, Debra Hawes, John M Ringman, Michael S Bienkowski · 2025
Read Characterizing Tau Neuropathology Across Brain Regions in Patients Carrying PSEN1 Jalisco Mutation by Bayla M Breningstall, Evan Abdollahi, Anne Hiniker, Debra Hawes, John M Ringman, Michael S Bienkowski (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710846.txt.
Description
Bayla Breningstall and five co-authors map tau tangles across the brains of patients with a rare inherited Alzheimer's mutation, in a 2025 study. The Jalisco mutation, found in families of Mexican descent, causes early dementia plus unusual plaques and leg stiffness.
Tau in these patients had never been charted. The team stained brain sections from nine mutation carriers and nine advanced sporadic cases with a tau marker. Machine learning counted the stain across cortex, deep structures, and brainstem. Comparison groups carried two other presenilin mutations. The map shows where Jalisco tau falls heaviest and how it differs. Regional patterns may explain the mutation's odd motor symptoms.
Catalog record
| CREATOR | Bayla M Breningstall, Evan Abdollahi, Anne Hiniker, Debra Hawes, John M Ringman, Michael S Bienkowski |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |