Amygdala‐predominant α‐synuclein pathology accelerates CA1 neuron loss in Alzheimer’s disease
Klara Gawor, Sandra O Tomé, Simona Ospitalieri, Alicja Ronisz, Rik Vandenberghe, Markus Otto, Christine von Arnim, Philip Van Damme, Mathieu Vandenbulcke, Matthew Blaschko, Dietmar Rudolf Thal · 2025
Read Amygdala‐predominant α‐synuclein pathology accelerates CA1 neuron loss in Alzheimer’s disease by Klara Gawor, Sandra O Tomé, Simona Ospitalieri, Alicja Ronisz, Rik Vandenberghe, Markus Otto, Christine von Arnim, Philip Van Damme, Mathieu Vandenbulcke, Matthew Blaschko, Dietmar Rudolf Thal (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710844.txt.
Description
Klara Gawor and ten colleagues examine donated brains, published in 2025, to see how a second disease protein changes Alzheimer damage. In many patients, a protein called alpha-synuclein also builds up in the wrong shape. It spreads in two main patterns: one rising from low brain areas, and one centered on the amygdala. The team asked whether the amygdala pattern speeds the loss of nerve cells in the hippocampus, a key memory area.
They studied two hundred ninety-one brains from older people, with and without dementia. Brains with the amygdala pattern had fewer nerve cells in a hippocampus zone called CA1. Those patients also showed more of the late-stage changes tied to TDP-43, another clumping protein. A statistical model linked the pattern to cell loss only through tau and TDP-43 buildup. The authors say mixed disease needs more attention in diagnosis and trials.
Catalog record
| CREATOR | Klara Gawor, Sandra O Tomé, Simona Ospitalieri, Alicja Ronisz, Rik Vandenberghe, Markus Otto, Christine von Arnim, Philip Van Damme, Mathieu Vandenbulcke, Matthew Blaschko, Dietmar Rudolf Thal |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |