Multi‐omics profiling of Alzheimer’s disease in multi‐ethnic populations
Joseph S Reddy, Laura M Heath, Mariet Allen, William L Poehlman, Yanling Wang, Ryan Johnson, Erming Wang, Yiyi Ma, Charlotte CG Ho, Katia de Paiva Lopes, Abby Vander Linden, Zachary Quicksall, Xianfeng Chen, Saurabh Baheti, Thuy Nguyen, Geovanna Yepez‐Sisalema, Adriana O Mitchell, Stephanie R Oatman · 2025
Read Multi‐omics profiling of Alzheimer’s disease in multi‐ethnic populations by Joseph S Reddy, Laura M Heath, Mariet Allen, William L Poehlman, Yanling Wang, Ryan Johnson, Erming Wang, Yiyi Ma, Charlotte CG Ho, Katia de Paiva Lopes, Abby Vander Linden, Zachary Quicksall, Xianfeng Chen, Saurabh Baheti, Thuy Nguyen, Geovanna Yepez‐Sisalema, Adriana O Mitchell, Stephanie R Oatman (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710841.txt.
Description
Joseph Reddy and co-authors profile Alzheimer's disease across ancestries with a stack of molecular measurements, in a 2025 paper. Most Alzheimer's knowledge comes from people of European descent, yet the disease hits African American and Latin American communities harder and may run on partly different biology. A dedicated diversity initiative within a big Alzheimer's partnership set out to close that gap with multi-omics data: genes, RNA, proteins, and more, measured in the same donors.
The project assembles brain and other samples from multi-ethnic cohorts and layers the molecular readouts. Early aims are descriptive and comparative: which pathways repeat across populations, and which differ. Such differences matter for biomarkers and drugs tuned on narrow data. The authors present the resource as groundwork for an Alzheimer's science that finally matches the disease's actual demographics.
Catalog record
| CREATOR | Joseph S Reddy, Laura M Heath, Mariet Allen, William L Poehlman, Yanling Wang, Ryan Johnson, Erming Wang, Yiyi Ma, Charlotte CG Ho, Katia de Paiva Lopes, Abby Vander Linden, Zachary Quicksall, Xianfeng Chen, Saurabh Baheti, Thuy Nguyen, Geovanna Yepez‐Sisalema, Adriana O Mitchell, Stephanie R Oatman |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |