Increased fibrin deposition in the brains of individuals with Down syndrome and Alzheimer’s disease
Annie Du, Lisi Flores‐Aguilar, Natalie C. Edwards, Patrick J. Lao, Jae Kyu Ryu, Katerina Akassoglou, Donna M. Wilcock, Julia Kofler, Milos D Ikonomovic, Florence Lai, Adam M. Brickman, Elizabeth Head · 2025
Read Increased fibrin deposition in the brains of individuals with Down syndrome and Alzheimer’s disease by Annie Du, Lisi Flores‐Aguilar, Natalie C. Edwards, Patrick J. Lao, Jae Kyu Ryu, Katerina Akassoglou, Donna M. Wilcock, Julia Kofler, Milos D Ikonomovic, Florence Lai, Adam M. Brickman, Elizabeth Head (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710835.txt.
Description
Annie Du and co-authors measure a clotting protein in the brains of people with Down syndrome and Alzheimer's disease. Their 2025 study notes that adults with Down syndrome have a high genetic risk of Alzheimer's. Most develop its brain changes in their forties. They have low rates of vessel risk factors, yet show vessel harm in the brain, such as tiny bleeds.
That pattern hints the blood brain barrier may leak, letting blood proteins into brain tissue. The protein studied, fibrin, marks such leaks and drives immune harm. Tissue from the back of the brain was stained and scanned. Twelve adults with both conditions were compared with twelve controls. The first group showed far higher fibrin in both white and grey matter.
Catalog record
| CREATOR | Annie Du, Lisi Flores‐Aguilar, Natalie C. Edwards, Patrick J. Lao, Jae Kyu Ryu, Katerina Akassoglou, Donna M. Wilcock, Julia Kofler, Milos D Ikonomovic, Florence Lai, Adam M. Brickman, Elizabeth Head |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |