Cholinergic white matter pathways in Alzheimer’s disease, dementia with Lewy bodies, and other neurodegenerative diseases: a post‐mortem MRI study
Francisco J. López‐González, Milan Nemy, Alberto Rabano, Michel J. Grothe, Pascual Sanchez‐Juan, Daniel Ferreira · 2025
Read Cholinergic white matter pathways in Alzheimer’s disease, dementia with Lewy bodies, and other neurodegenerative diseases: a post‐mortem MRI study by Francisco J. López‐González, Milan Nemy, Alberto Rabano, Michel J. Grothe, Pascual Sanchez‐Juan, Daniel Ferreira (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710832.txt.
Description
Francisco López-González and co-authors check a brain imaging claim against autopsy truth in this 2025 study. Living scans had suggested that the chemical messenger pathways for acetylcholine waste away in Alzheimer's disease and Lewy body dementia. The team scanned donated brains within hours of death and confirmed each diagnosis under the microscope.
Fifty-three donors took part: thirty-four with Alzheimer's, ten with Lewy body disease, and nine with other conditions. A diffusion measure that rises as fibers break down was read inside two known cholinergic pathways. Alzheimer's donors showed clearly worse pathways than both other groups. Lewy body donors sat between, worse than the others but not significantly in this small set. The authors say the post-mortem proof firms up the imaging story and sharpens the contrast between the two dementias.
Catalog record
| CREATOR | Francisco J. López‐González, Milan Nemy, Alberto Rabano, Michel J. Grothe, Pascual Sanchez‐Juan, Daniel Ferreira |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |