A Common Epitope in p53 and Tau Protein Aggregates
David Lynch, Nemil Bhatt, Madison Samples, Madeline Demny, Phanourios Tamamis, Rakez Kayed · 2025
Read A Common Epitope in p53 and Tau Protein Aggregates by David Lynch, Nemil Bhatt, Madison Samples, Madeline Demny, Phanourios Tamamis, Rakez Kayed (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710830.txt.
Description
David Lynch, Nemil Bhatt, Madison Samples, Madeline Demny, Phanourios Tamamis, and Rakez Kayed report laboratory work, published in 2025, on two proteins that clump in the Alzheimer brain. One is tau, a well known marker of the disease. The other is p53, a protein that normally helps repair damaged DNA. Earlier work from the same lab found p53 clumps in Alzheimer cases but not in healthy controls, sometimes mixed with tau.
The team tested whether antibodies made to spot one clumped protein would also bind the other. They used lab-made normal and mutant forms of both proteins, plus tissue from Alzheimer mouse models and patients. An antibody built for clumped p53 also reacted with tau, and tau antibodies reacted back, even though the two proteins share no matching sequence. The shared shape both proteins take when clumped could become a target for antibody treatment.
Catalog record
| CREATOR | David Lynch, Nemil Bhatt, Madison Samples, Madeline Demny, Phanourios Tamamis, Rakez Kayed |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |