Apolipoprotein ε genotype and sex influences skeletal muscle bioenergetic response to diet
Chelsea N Johnson, Colton R Lysaker, Colin S McCoin, Riley E Kemna, Casey S John, John P Thyfault, Heather M Wilkins, Paige C Geiger, Jill K Morris · 2025
Read Apolipoprotein ε genotype and sex influences skeletal muscle bioenergetic response to diet by Chelsea N Johnson, Colton R Lysaker, Colin S McCoin, Riley E Kemna, Casey S John, John P Thyfault, Heather M Wilkins, Paige C Geiger, Jill K Morris (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710828.txt.
Description
Chelsea N Johnson and co-authors study diet, sex, and gene effects on muscle energy in a 2025 mouse report. The APOE4 gene variant is the strongest common genetic risk for Alzheimer's disease, and its carriers show altered body metabolism. Muscle burns much of the body's fuel, yet how the variant affects muscle was little known.
The team fed mice with the human APOE3 or APOE4 gene a high-fat or low-fat diet for four months. In females with APOE4, the low-fat diet already shifted energy proteins. The high-fat diet changed hundreds of muscle proteins in that group alone, and raised their fuel burning. Other groups changed far less. The authors say muscle may help explain how this gene shapes whole-body metabolism.
Catalog record
| CREATOR | Chelsea N Johnson, Colton R Lysaker, Colin S McCoin, Riley E Kemna, Casey S John, John P Thyfault, Heather M Wilkins, Paige C Geiger, Jill K Morris |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |