Synaptic proteasome is inhibited in Alzheimer’s disease models and associates with memory impairment in mice
Felipe C Ribeiro, Danielle Cozachenco Ferreira, Luana Heimfarth, Juliana Fortuna, Guilherme B. de Freitas, Jorge M Souza, Soniza Alves‐Leon, Renata Elaine Paraizo Leite, Claudia Kimie Suemoto, Lea T. Grinberg, Fernanda G De Felice, Mychael V Lourenco, Sergio T Ferreira · 2025
Read Synaptic proteasome is inhibited in Alzheimer’s disease models and associates with memory impairment in mice by Felipe C Ribeiro, Danielle Cozachenco Ferreira, Luana Heimfarth, Juliana Fortuna, Guilherme B. de Freitas, Jorge M Souza, Soniza Alves‐Leon, Renata Elaine Paraizo Leite, Claudia Kimie Suemoto, Lea T. Grinberg, Fernanda G De Felice, Mychael V Lourenco, Sergio T Ferreira (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710822.txt.
Description
Felipe C Ribeiro and co-authors report a 2025 study of the proteasome, the cell machine that clears worn-out proteins at synapses. The machine supports memory by keeping synapse proteins in balance. The team asked whether it fails in Alzheimer's disease, using human brain tissue, cell cultures, and mouse models.
They found more tagged waste proteins in patient hippocampus tissue than in controls. Amyloid clumps cut the machine's activity at synapses and lowered its numbers there. Blocking the machine in mice caused spine loss, stress damage, and poor memory. A drug called rolipram restored the machine's work in mice. The authors link this failure to synapse and memory loss.
Catalog record
| CREATOR | Felipe C Ribeiro, Danielle Cozachenco Ferreira, Luana Heimfarth, Juliana Fortuna, Guilherme B. de Freitas, Jorge M Souza, Soniza Alves‐Leon, Renata Elaine Paraizo Leite, Claudia Kimie Suemoto, Lea T. Grinberg, Fernanda G De Felice, Mychael V Lourenco, Sergio T Ferreira |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |