Higher Gene Expression Of Dynein Heavy Chains In The Dorsolateral Prefrontal Cortex Predict Lower Neuropathology Burden And Better Cognitive Outcomes In Individuals With Alzheimer’s Disease
Esteban M Lucero, Tonya Brunetti, Heidi J Chial, Huntington Potter, Chris Gignoux · 2025
Read Higher Gene Expression Of Dynein Heavy Chains In The Dorsolateral Prefrontal Cortex Predict Lower Neuropathology Burden And Better Cognitive Outcomes In Individuals With Alzheimer’s Disease by Esteban M Lucero, Tonya Brunetti, Heidi J Chial, Huntington Potter, Chris Gignoux (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710802.txt.
Description
Esteban Lucero and co-authors link higher dynein gene expression in a frontal brain region to lighter Alzheimer burden, in work from twenty twenty-five. Motor proteins haul cargo inside neurons and shape memory circuits. Past mouse work showed one motor can override amyloid harm to synapses. This study tests dynein motors in human brain data instead. Gene, pathology, and cognition records come from a large ageing study.
Hundreds of donors supply gene reads from the dorsolateral prefrontal cortex. Models adjust for age, sex, schooling, and post-mortem delay. In donors with Alzheimer disease, two dynein genes stand out. Higher expression of each predicts better cognition over time. Higher expression also predicts better scores at the last visit before death. Lower pathology burden tracks with the same high expression pattern. Motor support may buffer brains against amyloid damage.
Catalog record
| CREATOR | Esteban M Lucero, Tonya Brunetti, Heidi J Chial, Huntington Potter, Chris Gignoux |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |