Reduction of central arterial stiffness by senolytic quercetin improves age‐associated decline in cognitive function in a Dahl salt‐sensitive rat model of early vascular aging
Carla Rocha Dos Santos, Mackenzie J Barnett, Ross A McDevitt, Wen Wei, Valentina I Zernetkina, Ondrej Juhasz, Christopher H Morrell, Edward G Lakatta, Olga V Fedorova · 2025
Read Reduction of central arterial stiffness by senolytic quercetin improves age‐associated decline in cognitive function in a Dahl salt‐sensitive rat model of early vascular aging by Carla Rocha Dos Santos, Mackenzie J Barnett, Ross A McDevitt, Wen Wei, Valentina I Zernetkina, Ondrej Juhasz, Christopher H Morrell, Edward G Lakatta, Olga V Fedorova (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710783.txt.
Description
Carla Rocha Dos Santos and co-authors test a plant compound in rats bred for salt-sensitive blood pressure and early vessel aging. Stiff central arteries track with fading thought in aging humans. The compound, quercetin, clears worn-out cells and calms swelling. Their 2025 study feeds it to rats on a normal salt diet for three months and tracks pressure, artery stiffness, heart scans, and attention.
Untreated rats grew stiffer and tenser with age, and their attention slipped. Treated rats ended with lower pressure and stiffness, stronger heart pumping, and more correct picks on a brief-flash attention test. The attention gain tracked stiffness, not pressure. The authors say artery stiffness may drive thought loss through paths beyond pressure itself.
Catalog record
| CREATOR | Carla Rocha Dos Santos, Mackenzie J Barnett, Ross A McDevitt, Wen Wei, Valentina I Zernetkina, Ondrej Juhasz, Christopher H Morrell, Edward G Lakatta, Olga V Fedorova |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |