Microglial extracellular vesicles’ proteome sheds light on the mechanisms underlying Alzheimer’s disease progression
Martina Gabrielli, Elisa Tonoli, Elisabetta Battocchio, Clare Coveney, David Boocock, Ottavio Arancio, Elisabetta A M Verderio, Claudia Verderio · 2025
Read Microglial extracellular vesicles’ proteome sheds light on the mechanisms underlying Alzheimer’s disease progression by Martina Gabrielli, Elisa Tonoli, Elisabetta Battocchio, Clare Coveney, David Boocock, Ottavio Arancio, Elisabetta A M Verderio, Claudia Verderio (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710774.txt.
Description
Gabrielli and co-authors catalog the proteins inside bubbles released by the brain's immune cells in Alzheimer's disease, in this 2026 conference abstract. Earlier work showed these vesicles, when loaded with the amyloid protein, travel along axons and spread synaptic harm in mice. Loaded vesicles move farther than plain ones, for reasons unknown.
The team brewed vesicles from microglia fed the amyloid fragment and read their protein cargo with mass spectrometry. About one hundred fifty proteins rose and a similar number fell compared with plain vesicles. Pathway analysis pointed to systems for movement and energy. A glue-like enzyme also drew attention in follow-up imaging tests. The cargo map may explain the vesicles' reach.
Catalog record
| CREATOR | Martina Gabrielli, Elisa Tonoli, Elisabetta Battocchio, Clare Coveney, David Boocock, Ottavio Arancio, Elisabetta A M Verderio, Claudia Verderio |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |