Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease‐related Aβ pathology
Renzo Mancuso · 2025
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Description
Mancuso reports a 2025 study of human brain immune cells grown in mice. The cells, called microglia, sit at the heart of Alzheimer's disease, yet human samples are hard to study. Stem-cell-grown human microglia were placed into mice with amyloid buildup. Over 138,000 single-cell gene profiles were gathered from the grafted cells.
The human cells took on a disease-linked state much like mouse cells show. They also showed a stronger antigen-display state near amyloid plaques. A second response fired against loose amyloid forms, rich in signal molecules. Removing key risk genes changed these responses in distinct ways. The author says drug studies should track all these states, not just one.
Catalog record
| CREATOR | Renzo Mancuso |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 1 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |