Presynaptic toxicity of the AD susceptibility gene BIN1
Pierre Dourlen, Erwan Lambert, Alejandra Freire‐Regatillo, Carla Gelle, Valentin Leclerc, Nicolas Barois, Xavier Hermant, Tommy Malfoi, Patrik Verstreken, Philippe Amouyel, Frank Lafont, Devrim Kilinc, Jean‐Charles Lambert · 2025
Read Presynaptic toxicity of the AD susceptibility gene BIN1 by Pierre Dourlen, Erwan Lambert, Alejandra Freire‐Regatillo, Carla Gelle, Valentin Leclerc, Nicolas Barois, Xavier Hermant, Tommy Malfoi, Patrik Verstreken, Philippe Amouyel, Frank Lafont, Devrim Kilinc, Jean‐Charles Lambert (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710770.txt.
Description
Pierre Dourlen and co-authors pin a toxic role on one form of BIN1, a top Alzheimer risk gene. Their twenty twenty-five study starts from a fly finding: the isoform one variant swells early endosomes and kills neurons, an effect kept in human neurons grown in dishes. Endosome traffic also runs the synapse.
The team now traces that variant at the synapse itself, using fly eye neurons and larval junctions. Electrical reads, stains, and electron images map the damage. Other isoforms did not share the harm, which sharpens the blame. Naming the guilty variant gives drug hunters a precise target instead of the whole gene.
Catalog record
| CREATOR | Pierre Dourlen, Erwan Lambert, Alejandra Freire‐Regatillo, Carla Gelle, Valentin Leclerc, Nicolas Barois, Xavier Hermant, Tommy Malfoi, Patrik Verstreken, Philippe Amouyel, Frank Lafont, Devrim Kilinc, Jean‐Charles Lambert |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |