Exploring the Relationship Between Adipose Tissue and Alzheimer’s Disease Pathogenesis
Miriam Bettinetti‐Luque, Laura Trujillo‐Estrada, Juana Andreo‐Lopez, Cynthia Campos‐Moreno, Ivan Fatuarte‐Juli, Mario Morales‐Cabello, Celia Da Cunha, Elisabeth Sanchez‐Mejias, Frank M LaFerla, Antonia Gutierrez, David Baglietto‐Vargas · 2025
Read Exploring the Relationship Between Adipose Tissue and Alzheimer’s Disease Pathogenesis by Miriam Bettinetti‐Luque, Laura Trujillo‐Estrada, Juana Andreo‐Lopez, Cynthia Campos‐Moreno, Ivan Fatuarte‐Juli, Mario Morales‐Cabello, Celia Da Cunha, Elisabeth Sanchez‐Mejias, Frank M LaFerla, Antonia Gutierrez, David Baglietto‐Vargas (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710762.txt.
Description
Miriam Bettinetti-Luque and co-authors explore fat tissue and Alzheimer's disease in a 2025 mouse study. Obesity and type two diabetes raise the risk of the disease, and both expand belly fat. The team asked whether that fat sends signals that change the brain.
They moved belly fat pads from diabetic mice into mice bred to develop Alzheimer's-like changes. The grafts raised tau damage and fired up microglia, the brain's immune cells. At the same time, amyloid plaques fell, as microglia ate more of the protein. The split result shows fat tissue talks to the brain through the immune system. It also warns that one change can help one disease sign while harming another.
Catalog record
| CREATOR | Miriam Bettinetti‐Luque, Laura Trujillo‐Estrada, Juana Andreo‐Lopez, Cynthia Campos‐Moreno, Ivan Fatuarte‐Juli, Mario Morales‐Cabello, Celia Da Cunha, Elisabeth Sanchez‐Mejias, Frank M LaFerla, Antonia Gutierrez, David Baglietto‐Vargas |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |