Computational search for the interactors of alternatively spliced TREM2 isoforms
Junyi Liang, Aditya Aditya Menon, Taylor Tomco, Lynn M Bekris, Group of GMI staff Dr. Lynn Bekris · 2025
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Description
Junyi Liang and co-authors report a 2025 computer search for partners of variant forms of the TREM2 protein. TREM2 is one of the strongest genetic risk factors for Alzheimer's disease. The protein helps brain immune cells clear amyloid and switch on. It comes in three forms made by alternative splicing of its gene. Known partners include the amyloid protein itself and a carrier protein. Little is known about what each spliced form binds to.
The study predicts binding partners for all three forms by computer methods. It builds on the one known case where a partner protein is marked for disposal through this contact. Finding form-specific partners could explain why the variants matter for disease. The work is computational, a search for leads rather than lab proof. Those leads can guide bench tests on brain immune cells. The authors frame the results as a map for follow-up studies.
Catalog record
| CREATOR | Junyi Liang, Aditya Aditya Menon, Taylor Tomco, Lynn M Bekris, Group of GMI staff Dr. Lynn Bekris |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |