Reactive astrocytes with reduced function of glutamate transporters in the AppNL‐G‐F knock‐in mice
Raúl Loera‐Valencia, Ipsit Srivastava, Julen Goikolea, Tamer Ayberk Kaya, Maria Latorre Leal, Marta Pereira Iglesias, Laura Alvarez‐Jimenez, Luis Enrique Arroyo‐García, Makoto Shimozawa, Per Nilsson, André Fisahn, Maria Lindskog, Silvia Maioli · 2025
Read Reactive astrocytes with reduced function of glutamate transporters in the AppNL‐G‐F knock‐in mice by Raúl Loera‐Valencia, Ipsit Srivastava, Julen Goikolea, Tamer Ayberk Kaya, Maria Latorre Leal, Marta Pereira Iglesias, Laura Alvarez‐Jimenez, Luis Enrique Arroyo‐García, Makoto Shimozawa, Per Nilsson, André Fisahn, Maria Lindskog, Silvia Maioli (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710756.txt.
Description
Raul Loera-Valencia and co-authors present a 2025 mouse study of star shaped support cells in Alzheimer's disease. In a gene edited model that grows amyloid plaques, these cells turn reactive around the plaques. Their key job, mopping up the signal chemical glutamate, was measured live for the first time in this model.
The mop up current was badly impaired in sick mice at mid life. Yet the transporter protein's amount was unchanged, in both synapse samples and sorted cells. So the failure is one of function, not supply. Left over glutamate could harm synapses. The authors suggest restoring this cell function as a treatment angle.
Catalog record
| CREATOR | Raúl Loera‐Valencia, Ipsit Srivastava, Julen Goikolea, Tamer Ayberk Kaya, Maria Latorre Leal, Marta Pereira Iglesias, Laura Alvarez‐Jimenez, Luis Enrique Arroyo‐García, Makoto Shimozawa, Per Nilsson, André Fisahn, Maria Lindskog, Silvia Maioli |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |