Autologous macrophages stimulated by epoxides of polyunsaturated fatty acids and protected by inhibitors of soluble epoxide hydrolase or cGAS/STING pathway repair amyloid‐β pathology in the Alzheimer’s disease (AD) brain
Milan Fiala, Julian Whitelegge, Bruce D Hammock, Santosh Kesari · 2025
Read Autologous macrophages stimulated by epoxides of polyunsaturated fatty acids and protected by inhibitors of soluble epoxide hydrolase or cGAS/STING pathway repair amyloid‐β pathology in the Alzheimer’s disease (AD) brain by Milan Fiala, Julian Whitelegge, Bruce D Hammock, Santosh Kesari (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710741.txt.
Description
Milan Fiala and co-authors present a 2025 study on immune cells and amyloid in the Alzheimer's brain. In health, macrophages clear amyloid protein from brain tissue. In patients, these cells turn inflamed and lose the tools that break amyloid down, so the protein builds up.
The team treated patient macrophages with fatty acid epoxides plus drugs that block one of two pathways. The treated cells regained a calmer state and the tools needed to digest amyloid. In lab tests they took up more amyloid within two hours and broke down more of it within a day. The authors propose that calming these cells could one day help restore memory in patients.
Catalog record
| CREATOR | Milan Fiala, Julian Whitelegge, Bruce D Hammock, Santosh Kesari |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |