Behavioral studies in a new mouse model of hemochromatosis mutations and Alzheimer’s amyloidosis
Elvis Acquah, Daniel Johnstone, Adrienne (Lz) Milward · 2025
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Description
Elvis Acquah, Daniel Johnstone, and Adrienne Milward test whether faulty brain iron handling alone impairs behavior, using a new mouse line, in a 2025 study. Iron imbalance shows in Alzheimer's brains, but cause and symptom are tangled. Their mice carry hemochromatosis mutations that overload brain iron, alone or combined with an amyloid-producing Alzheimer's model.
Brain iron ran 1.5 times normal at three months, rising with age. Iron alone left spatial learning, flexibility, and recognition memory untouched. It did quicken anxiety-like behavior in males when amyloid was present, and it cut movement in maze tests for both sexes at six months, an effect that faded by nine months. The authors conclude iron mis-handling tweaks activity and anxiety more than cognition.
Catalog record
| CREATOR | Elvis Acquah, Daniel Johnstone, Adrienne (Lz) Milward |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |