Using disease‐selective cell lines to investigate tau strain biology
Sara A M Holec, Christine K Brown, Matthew P Frost, Amanda L Woerman · 2025
Read Using disease‐selective cell lines to investigate tau strain biology by Sara A M Holec, Christine K Brown, Matthew P Frost, Amanda L Woerman (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710735.txt.
Description
Sara Holec and co-authors build cell lines that can tell tau strains apart by disease. Tau protein folds into distinct shapes, or strains, and the shape picks the disease. Past cell tests could split strains by protein version but not within one version. Their 2025 study seeds kidney cells with single-letter changes in the tau gene. The changes were picked by modeling to block one disease's strain and not another's.
Corticobasal degeneration and progressive supranuclear palsy are the test pair. Growth setups were tuned in tiny wells with mouse tau seeds first. Human patient samples then face the panel. If a line grows one strain and shuns the other, strain-specific tests become possible.
Catalog record
| CREATOR | Sara A M Holec, Christine K Brown, Matthew P Frost, Amanda L Woerman |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |