The klotho F/C AD risk haplotype drives distinct phenotypes in a novel mouse model
Michael Sasner, Ravi S Pandey, Kevin P Kotredes, Dylan Garceau, Channing Weber, Rafiou Agoro, Christoph Preuss, Gregory W Carter · 2025
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Description
Michael Sasner and seven co-authors build a mouse model for a gene twist that shifts Alzheimer risk in a 2025 study. People with the APOE4 gene form face high risk, yet some escape the disease. A second gene, klotho, comes in forms that guard those carriers or leave the risk in place.
Mouse klotho matches neither human form at the key spot. Using gene editing, the team swapped in each human form in turn. They then tracked klotho levels in blood, brain, and kidney against normal mice. The risk form drove distinct traits, which opens a way to test how the gene interplay drives disease.
Catalog record
| CREATOR | Michael Sasner, Ravi S Pandey, Kevin P Kotredes, Dylan Garceau, Channing Weber, Rafiou Agoro, Christoph Preuss, Gregory W Carter |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |