Seizure‐activated neurons facilitate tau spread in 5XFAD mice
Aaron J Barbour, Abigail Chavez, Keegan Hoag, Xiaofan Li, Chloe Hassman, Virginia M‐Y Lee, Delia M Talos, Frances E Jensen · 2025
Read Seizure‐activated neurons facilitate tau spread in 5XFAD mice by Aaron J Barbour, Abigail Chavez, Keegan Hoag, Xiaofan Li, Chloe Hassman, Virginia M‐Y Lee, Delia M Talos, Frances E Jensen (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710728.txt.
Description
Aaron Barbour and co-authors test whether seizures help the faulty tau protein spread in a mouse model of Alzheimer's disease. Seizures are common in Alzheimer's, and past work shows they worsen outcomes. Tau spread along nerve links drives the disease, but seizure effects on that spread were unknown. Their 2025 study uses mice bred so seizure-active cells can be tagged for life.
Human Alzheimer's tau was seeded into one side of the brain, then seizures were triggered in some mice. Alzheimer's-model mice built more tau damage near the seed site than plain mice, with or without seizures. Seizures did add spread to far, linked regions in both brain halves, the head text reports. The work points to seizure control as one lever on disease pace.
Catalog record
| CREATOR | Aaron J Barbour, Abigail Chavez, Keegan Hoag, Xiaofan Li, Chloe Hassman, Virginia M‐Y Lee, Delia M Talos, Frances E Jensen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |