PS1 regulates processing and angiogenic signalling of VEGFR2; effects of FAD mutants
Poulomi Dey, Rukmani Pandey, Amira Zarrouk, Glikeria Tzikas, Anastasios Georgakopoulos, Nikolaos K. R K Robakis · 2025
Read PS1 regulates processing and angiogenic signalling of VEGFR2; effects of FAD mutants by Poulomi Dey, Rukmani Pandey, Amira Zarrouk, Glikeria Tzikas, Anastasios Georgakopoulos, Nikolaos K. R K Robakis (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710689.txt.
Description
Poulomi Dey and co-authors study how a protein tied to Alzheimer's disease shapes blood vessel growth signals, in a 2025 paper. The protein, called PS1, helps run a cutting tool inside cells. Faulty forms of the gene behind it cause a rare inherited form of the disease.
The team tested how normal and faulty forms of the protein handle a vessel growth receptor. Faulty forms cut the receptor far less, much like a drug that blocks the cutting tool. Binding tests showed the protein still grips the receptor, so the flaw lies in cutting, not grip. Lowering the protein in vessel cells also changed growth signals. The work links disease mutations to vessel faults beyond the brain.
Catalog record
| CREATOR | Poulomi Dey, Rukmani Pandey, Amira Zarrouk, Glikeria Tzikas, Anastasios Georgakopoulos, Nikolaos K. R K Robakis |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |