LUHMES Cells: In Vitro Model for Studying Tauopathy in Alzheimer’s Disease
Madeline Moffett, Mayur S Parmar · 2025
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Description
Madeline Moffett and Mayur Parmar review a human cell line that may help labs study tau, a protein that clumps in Alzheimer's disease. Most cell lines used for this work lack nerve cell traits and do not make their own tau. The line they cover, called LUHMES, comes from human brain tissue and does make tau on its own.
The review gathers studies that used these cells to model tau disease. In one, a drug undid tau clumping caused by a toxin. In another, switching on a cell stress sensor cut the chemical tagging that leads to clumps. The authors argue the line deserves wider use in drug screening for tau faults.
Catalog record
| CREATOR | Madeline Moffett, Mayur S Parmar |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |