Epigenetic signatures of genetic risk in Alzheimer’s disease
Sarah Marzi · 2025
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Description
Sarah Marzi studies how gene risk for Alzheimer disease shows up in the brain's immune cells, in work published in 2025. Those cells, called microglia, help defend the brain. Genetic risk for the disease clusters in the switch regions that control microglia genes. Marzi asked how risk burden changes those switches, using both a mouse model and human brain tissue.
Human microglia grown from stem cells were placed into mice bred for the disease. The cells carried different forms of APOE, the strongest common risk gene. As risk rose from the safer form to the riskiest, the cells turned up inflammation signals. Helpful cell states linked to defense were turned down. In donated human brains, microglia showed wide changes in the same switch regions. Some changes could be tied straight to gene variants. The work links inherited risk to the cell changes seen in disease.
Catalog record
| CREATOR | Sarah Marzi |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |