Cognitive integrity in Non‐Demented Individuals with Alzheimer’s Disease Neuropathology is associated with preservation and remodeling of dendritic spines
Jutatip Guptarak, Pietro Scaduto, Batbayar Tumurbaatar, Daniel Jupiter, Giulio Taglialatela, Anna Fracassi · 2025
Read Cognitive integrity in Non‐Demented Individuals with Alzheimer’s Disease Neuropathology is associated with preservation and remodeling of dendritic spines by Jutatip Guptarak, Pietro Scaduto, Batbayar Tumurbaatar, Daniel Jupiter, Giulio Taglialatela, Anna Fracassi (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710627.txt.
Description
Jutatip Guptarak and five colleagues present a 2025 brain study of people who die with Alzheimer's damage yet never lost their memory. Such people, called non-demented with Alzheimer's pathology, may hold clues to resisting the disease. The team compared the frontal cortex of these brains with tissue from Alzheimer's patients and healthy controls of similar age.
They measured the tiny spines where nerve cells receive signals, both near and far from amyloid plaques. Close to plaques, connections suffered in every group. Farther away, the resilient brains kept more spines than Alzheimer's brains, favoring young, flexible spine types over stable mature ones. A protein called Pin1, tied to spine upkeep, also featured in the analysis. Constant remodeling may be how these brains stay sharp.
Catalog record
| CREATOR | Jutatip Guptarak, Pietro Scaduto, Batbayar Tumurbaatar, Daniel Jupiter, Giulio Taglialatela, Anna Fracassi |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |